The soprano received her vocal training as a master student with Kammersänger Peter Gougaloff (Deutsche Oper Berlin) after completing her instrumental studies at the Hanover School of Music and Theatre. Later her bel canto studies brought her together with Mirella Freni.

Opera and concert performances have taken her to Switzerland, the US, Denmark, Poland, Lithuania, the Czech Republic, Romania and Germany. Among others, she has participated in radio, TV and CD recordings for the Danish national radio, TV Kraków, the Lithuanian national radio, Bucharest television, Deutschlandradio, Deutschlandfunk, Westdeutscher and Hessischer Rundfunk and the labels Profil Hänssler and Dreyer-Gaido, as well as the Potsdamer Bibliothek östliches Europa publication series.

She made her opera debut in Switzerland as Micaëla in Bizet‘s Carmen. Her most notable roles since then have included Donna Elvira in Mozart‘s Don Giovanni, Violetta in Verdi‘s La Traviata (which soon became her best role), Konstanze in Mozart‘s The Abduction from the Seraglio and Agathe in Weber‘s Der Freischütz.

Recitals have become a major component in her work as an artist. She has performed at several prestigious international festivals, including the Schleswig-Holstein Musikfestival, the Festival Mitte Europa, the Internationaler Musiksommer “NordTöne”, the Reconstruction Concerts for the Dresden Frauenkirche, the Lausitzer Musiksommer, the Summer Festival at Rosenholm Castle, Denmark, the Karol Szymanowski Music Days in Zakopane, Poland, the Christopher Summer Festival in Vilnius, Lithuania, and the International Festival of Lyrical Art, which was held as part of the European Cultural Capital 2007 programme in Sibiu, Romania. Verena Rein is further known as a performer of different styles of contemporary music, from duets to vocal works with orchestra. Since 1998, the soprano has been greatly successful in conducting master classes both in Germany and abroad on such diverse subjects as stage performance and stage presence training, lieder interpretation, classical Italian bel canto techniques, and breath and timbre control. She held a chair at Shenandoah University in Winchester, VA and from 2006 to 2009 taught performance and stage presence classes at the Berlin University of the Arts. Verena Rein also writes articles on music-related topics for various publications.